UK Researchers Discover Key Cause of Inflammatory Bowel Disease and Potential Treatment

Scientists in the UK have made a breakthrough in understanding and potentially treating inflammatory bowel disease (IBD).

This condition includes Crohn’s disease and ulcerative colitis. IBD affects over half a million people in the UK. Symptoms often start in adolescence or early adulthood. The condition is uncommon among Africans, although recent studies suggest a rising incidence.

Researchers at the Francis Crick Institute, in collaboration with University College London and Imperial College London, identified a section of DNA that plays a crucial role in the disease. This DNA segment is found in about 95% of IBD patients and influences the activity of immune cells called macrophages. These cells flood the intestines and release chemicals known as cytokines. The cytokines, in turn, cause excessive inflammation.  Aside from genetics, environmental triggers such as diet and antibiotic use play a role in the development of IBD.

RAY OF HOPE‎

Dr James Lee from the Francis Crick Institute explained:

This is undoubtedly one of the central pathways that goes wrong for people to get inflammatory bowel disease. It is the process by which one of the most important cells that causes inflammatory bowel disease goes wrong.

Further experiments using patient samples revealed that existing drugs, initially designed for other conditions like cancer, could reverse this excessive inflammation in laboratory settings. While these findings are promising, researchers are now focused on finding ways to target these drugs specifically to the affected immune cells to avoid side effects.

The discovery was detailed in the journal NATURE and funded by Crohn’s and Colitis UK, the Wellcome Trust, the Medical Research Council, and Cancer Research UK. The research is a significant step toward developing more effective treatments for inflammatory bowel disease. Researchers aim to start clinical trials within five years.

BBC quoted Ruth Wakeman from Crohn’s & Colitis UK as stating:

This research is a fascinating step towards the possibility of a world free from Crohn’s and colitis one day. Crohn’s and colitis are complex, lifelong conditions for which there is no cure, but research like this is helping us to answer some of the big questions about what causes them.

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